Abstract
The pharmacology and SAR of representative equine estogens is described. 17alpha-Dihydroequilenin was found to prevent bone loss after 5 weeks of oral administration to ovariectomized rats. The stereochemical significance of the D-ring and the C/D ring juncture was investigated with a series of benzothiophene-based equilenin analogues.
MeSH terms
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Animals
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Equilin / analogs & derivatives
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Equilin / chemical synthesis
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Equilin / chemistry
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Equilin / pharmacology*
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Estradiol Congeners / administration & dosage
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Estradiol Congeners / chemical synthesis
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Estradiol Congeners / chemistry
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Estradiol Congeners / pharmacology*
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Female
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Models, Molecular
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Molecular Conformation
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Organ Size / drug effects
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Ovariectomy
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Rats
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Stereoisomerism
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Structure-Activity Relationship
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Uterus / anatomy & histology
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Uterus / drug effects
Substances
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Estradiol Congeners
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Equilin
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dihydroequilin